Many women, especially over 40, experience persistent fatigue that doesn’t seem to have a clear cause. It’s not just “getting older,” and it’s not in your head.
One possible (and often overlooked) reason? Hormonal exhaustion.
Hormonal exhaustion happens when your body is under chronic stress, (physical, emotional, or environmental) – and your hormonal systems (especially the adrenal glands) become disregulated. The result? Your energy, mood, metabolism, and even motivation all take a hit.
This is particularly common for women entering perimenopause or menopause, where hormone fluctuations naturally become more dramatic.
So, here’s what’s actually happening under the surface:
These are two of your key sex hormones. In your reproductive years, they rise and fall in a fairly predictable pattern. But as you approach menopause, they become more erratic, and eventually decline.
Estrogen affects serotonin and other neurotransmitters that regulate energy, mood, and sleep.
Progesterone has a calming, soothing effect on the brain, it’s like nature’s anti-anxiety hormone. When it drops, sleep quality often suffers and stress sensitivity increases.
The result: You feel more wired, anxious, and less rested – even after sleep.
With lower estrogen and progesterone, your body becomes more reactive to stress. That means cortisol, your main stress hormone, stays elevated longer than it should.
Chronic high cortisol leads to:
Poor sleep quality
Midsection fat gain
Sugar cravings
Suppressed thyroid function (slows metabolism)
Blood sugar swings
Energy crashes
The result: You’re stuck in a “tired but wired” cycle – fatigued all day but restless at night.
Melatonin is your sleep hormone, and it’s closely tied to cortisol and estrogen. When cortisol stays too high in the evening (hello, stress!), melatonin production drops.
You struggle to fall asleep or stay asleep
You wake up feeling unrefreshed
Your sleep isn’t as deep or restorative
The result: Sleep doesn’t “work” the way it used to – and you can’t recover the same way from stress or exercise.
Your thyroid controls metabolism and energy production. The hormonal changes in perimenopause can increase the risk of subclinical hypothyroidism (low thyroid activity), especially if you’re under chronic stress or not eating enough.
Signs include:
Sluggishness
Weight gain
Cold hands/feet
Low mood or “foggy” brain
The result: You feel constantly drained, even if you’re doing all the “right things.”
You don’t have to accept fatigue as your “new normal.” Here are a few powerful, hormone-supportive changes that can help: